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# Pembrolizumab-scFv Optimiziation Variants Iter0 x PD-1 (YM_0852)
## Overview
YM_852 are Pembrolizumab mutations against its native target; we introduce mutations that include deletions, insertions, double and single mutations to quantify the sensitivity of the local landscape in engaging the native target.
## Experimental details
This dataset includes 29883 unique scFvs and 1 unique native target sequence. A more extensive methods section can be found in our publication [here](https://pmc.ncbi.nlm.nih.gov/articles/PMC12296056/).
## Misc dataset details
We define the following binders:
### A-library (scFvs)
There are several terms you can filter by:
- `WT_<i>`: These are WT replicates.
- `del_<i>`: A deletion from the WT
- `ins_<i>`: An insertion from WT
- `pair_<i>`: A double mutation (2 residues mutated from WT)
- `single_<i>`: A single mutation
To get the mutations of interest relative to the parent, we recommend an alignment to the WT sequence.
### Alpha-library
There is only 1 sequence, which is the native target.
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